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Pravigard Pac e Malattia del fegato

Risultato del controllo d'interazione tra il farmaco Pravigard Pac e la malattia Malattia del fegato su sicurezza in caso d'uso simultaneo.

Risultato di controllo:

Pravigard Pac <> Malattia del fegato

Rilevanza: 23.07.2019 Recensore: P.M. Shkutko, dott., in

Durante il controllo d'interazione, secondo le fonti autorevoli Drugs.com, Rxlist.com, Webmd.com, Medscape.com sono trovate le controindicazioni o gli effetti collaterali che possono danneggiare oppure intensificare l’effetto negativo in caso d'uso del farmaco in presenza di questa malattia concomitante.

Consumatore:

L'uso di inibitori della HMG-CoA reduttasi inibitori è controindicato in pazienti con malattia epatica attiva o con inspiegabili persistenti aumenti delle transaminasi sieriche. Inibitori della HMG-CoA reduttasi sono ampiamente metabolizzato dal fegato. Diminuzione metabolismo del farmaco può portare ad accumulo e aumento del rischio di tossicità, tra cui anomalie biochimiche della funzione epatica e, raramente, ittero, epatite, cirrosi, steatosi cambiamento nel fegato, e necrosi epatica fulminante. La terapia con gli inibitori della HMG-CoA reduttasi inibitori devono essere somministrati con cautela in pazienti con una storia di malattia epatica e/o l'uso pesante dell'alcool. Un basso dosaggio iniziale può essere appropriato, e il monitoraggio clinico di fegato livelli di transaminasi in base al singolo prodotto, la confezione e l'etichettatura è raccomandato. I pazienti che sviluppano elevati di ALT o AST durante la terapia devono essere monitorati fino anomalie risolvere. Se un aumento superiore a 3 volte il limite superiore del normale persiste, deve essere presa in considerazione una riduzione del dosaggio o la revoca della terapia.

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