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Timolol and hydrochlorothiazide e Disturbi della funzionalità renale

Risultato del controllo d'interazione tra il farmaco Timolol and hydrochlorothiazide e la malattia Disturbi della funzionalità renale su sicurezza in caso d'uso simultaneo.

Risultato di controllo:

Timolol and hydrochlorothiazide <> Disturbi della funzionalità renale

Rilevanza: 23.07.2019 Recensore: P.M. Shkutko, dott., in

Durante il controllo d'interazione, secondo le fonti autorevoli Drugs.com, Rxlist.com, Webmd.com, Medscape.com sono trovate le controindicazioni o gli effetti collaterali che possono danneggiare oppure intensificare l’effetto negativo in caso d'uso del farmaco in presenza di questa malattia concomitante.

Consumatore:

I diuretici tiazidici possono essere inefficaci quando la velocità di filtrazione glomerulare è bassa (velocità di filtrazione glomerulare < 25 mL/min), perché non dovrebbero essere filtrati in un tubulo renale, il loro sito d'azione. Inoltre, i diuretici tiazidici diminuire la velocità di filtrazione glomerulare e può precipitare l'azotemia nella malattia renale. Effetti cumulativi possono sviluppare anche perché la maggior parte di questi farmaci sono escreto immodificato nelle urine attraverso la filtrazione glomerulare e secrezione tubulare attiva. La terapia con diuretici tiazidici devono essere somministrati con cautela a dosaggi ridotti in pazienti con insufficienza renale. Se la funzione renale diventa progressivamente peggio, come indicato dall'aumento PANINO o i livelli di creatinina sierica, di una sospensione o l'interruzione della terapia con tiazidici devono essere considerati.

Fonte

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