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Topcare Ibuprofen e Inibizione dell'aggregazione piastrinica

Risultato del controllo d'interazione tra il farmaco Topcare Ibuprofen e la malattia Inibizione dell'aggregazione piastrinica su sicurezza in caso d'uso simultaneo.

Risultato di controllo:
Topcare Ibuprofen <> Inibizione dell'aggregazione piastrinica
Rilevanza: 23.07.2019 Recensore: P.M. Shkutko, dott., in

Durante il controllo d'interazione, secondo le fonti autorevoli Drugs.com, Rxlist.com, Webmd.com, Medscape.com sono trovate le controindicazioni o gli effetti collaterali che possono danneggiare oppure intensificare l’effetto negativo in caso d'uso del farmaco in presenza di questa malattia concomitante.

Consumatore:

Farmaci anti-infiammatori non steroidei (Fans) reversibilmente inibire l'adesione delle piastrine e di aggregazione e possono prolungare il tempo di sanguinamento in alcuni pazienti. Con l'eccezione di aspirina, gli effetti delle piastrine visto con la maggior parte dei Fans al solito i dosaggi raccomandati sono generalmente lievi e di breve durata, ma può essere più pronunciato nei pazienti con sottostante emostatico anomalie. La trombocitopenia è stato segnalato raramente durante l'uso di FANS. La terapia con i Fans devono essere somministrati con cautela in pazienti con significativo sanguinamento attivo o diatesi emorragica, tra cui emostatico e/o difetti della coagulazione associato con l'emofilia, la carenza di vitamina K, hypoprothrombinemia, trombocitopenia, thrombocytopathy, o insufficienza epatica grave. Fans che inibiscono selettivamente la cicloossigenasi-2 (cioè, COX-2 inibitori) non sembrano influenzare la funzione piastrinica o tempo di sanguinamento a dosaggi indicati e può essere preferibile se il rischio di sanguinamento è una preoccupazione.

Fonte
  • Berliner S, Sidi Y, Shaklai M, Pinkhas J "Appearance of thrombocytopenia and benign monoclonal gammopathy following intake of drugs." Acta Haematol 67 (1982): 71-2
  • Leese PT, Hubbard RC, Karim A, Isakson PC, Yu SS, Geis GS "Effects of celecoxib, a novel cyclooxygenase-2 inhibitor, on platelet function in healthy adults: A randomized, controlled trial." J Clin Pharmacol 40 (2000): 124-32
  • Thwaites BK, Nigus DB, Bouska GW, Mongan PD, Ayala EF, Merrill GA "Intravenous ketorolac tromethamine worsens platelet function during knee arthroscopy under spinal anesthesia." Anesth Analg 82 (1996): 1176-81
  • Bernhard GC "Worldwide safety experience with nabumetone." J Rheumatol 19 (1992): 48-57
  • Katz ME, Wang P "Fenoprofen-associated thrombocytopenia." Ann Intern Med 92 (1980): 262
  • Gerber D "Adverse reactions of piroxicam." Drug Intell Clin Pharm 21 (1987): 707-10
  • Robb PJ, Rollin AM, Saunders DA "Diclofenac and post-tonsillectomy haemorrhage." Clin Otolaryngol 20 (1995): 483
  • "Product Information. Daypro (oxaprozin)." Searle, Skokie, IL.
  • Green D, Davies RO, Holmes GI et al "Effects of diflunisal on platelet function and fecal blood loss." Pharmacotherapy 3 (1983): s65-9
  • Baber N, Halliday LDC, van den Heuval, et al "Indomethacin in rheumatoid arthritis: clinical effects, pharmacokinetics, and platelet studies in responders and non-responders." Ann Rheum Dis 38 (1979): 128-37
  • O'Brien WM "Long-term efficacy and safety of tolmetin sodium in treatment of geriatric patients with rheumatoid arthritis and osteoarthritis: a retrospective study." J Clin Pharmacol 23 (1983): 309-23
  • Rosenbaum JT, O'Connor M "Thrombocytopenia associated with sulindac." Arthritis Rheum 24 (1981): 753-4
  • Buchanan GR, Martin V, Levine PH, et al "The effects of "anti-platelet" drugs on bleeding time and platelet aggregation in normal human subjects." Am J Clin Pathol 68 (1977): 355-9
  • "Product Information. Celebrex (celecoxib)." Searle, Chicago, IL.
  • Camba L, Joyner MV "Acute thrombocytopenia following ingestion of indomethacin." Acta Haematol 71 (1984): 350-2
  • Catalano MA "Worldwide safety experience with diclofenac." Am J Med 80 (1986): 81-7
  • "Product Information. Indocin (indomethacin)." Merck & Co, Inc, West Point, PA.
  • "Product Information. Lodine (etodolac)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
  • Bobrove AM "Diflunisal-associated thrombocytopenia in a patient with rheumatoid arthritis ." Arthritis Rheum 31 (1988): 148-9
  • Bjornstad H, Vik O "Thrombocytopenic purpura associated with piroxicam." Br J Clin Pract 40 (1986): 42
  • "Product Information. Naprosyn (naproxen)." Syntex Laboratories Inc, Palo Alto, CA.
  • Schattenkirchner M "An updated safety profile of etodolac in several thousand patients." Eur J Rheumatol Inflamm 10 (1990): 56-65
  • Longenecker GL, Swift IA, Bowen RJ, et al "Kinetics of ibuprofen effect on platelet and endothelial prostanoid release." Clin Pharmacol Ther 37 (1985): 343-8
  • "Product Information. Ansaid (flurbiprofen)." Pharmacia and Upjohn, Kalamazoo, MI.
  • "Product Information. Clinoril (sulindac)." Merck & Co, Inc, West Point, PA.
  • Sanz MA, Martinez JA, Gomis F, Garcia-Borras JJ "Sulindac-induced bone marrow toxicity." Lancet 2 (1980): 802-3
  • "Product Information. Orudis (ketoprofen)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
  • Epstein M, Vickars L, Stein H "Diclofenac induced immune thrombocytopenia." J Rheumatol 17 (1990): 1403-4
  • Bondeson J, Berglund S "Diclofenac-induced thrombocytopenic purpura with renal and hepatic involvement." J Intern Med 230 (1991): 543-7
  • Price AJ, Obeid D "Spontaneous non-gastrointestinal bleeding associated with diclofenac ." Lancet 2 (1989): 1520
  • Hirsh J, Dalen JE, Fuster V, Harker LB, Patrono C, Roth G "Aspirin and other platelet-active drugs: the relationship among dose, effectiveness, and side effects." Chest 108 Suppl (1995): s247-57
  • Kramer MR, Levene C, Hershko C "Severe reversible autoimmune haemolytic anaemia and thrombocytopenia associated with diclofenac therapy." Scand J Haematol 36 (1986): 118-20
  • Tomson G, Lunell N-O, Oliw E, Rane A "Relation of naproxen kinetics to effect on platelet prostaglandin release in men and dysmenorrheic women." Clin Pharmacol Ther 29 (1981): 168-73
  • Shojania AM, Rusen SD "Thrombocytopenia secondary to sulindac therapy." Can Med Assoc J 125 (1981): 1313
  • "Product Information. Relafen (nabumetone)." SmithKline Beecham, Philadelphia, PA.
  • "Product Information. Vioxx (rofecoxib)." Merck & Co, Inc, West Point, PA.
  • Gandini R, Cunietti E, Pappalepore V, et al "Effects of intravenous high doses of ketoprofen on blood clotting, bleeding time and platelet aggregation in man." J Int Med Res 11 (1983): 243
  • Park GD, Spector R, Headstream T, Goldberg M "Serious adverse reactions associated with sulindac." Arch Intern Med 142 (1982): 1292-4
  • Hyson CP, Kazakoff MA "A severe multisystem reaction to sulindac." Arch Intern Med 151 (1991): 387-8
  • Brooks CD, Linet OI, Schellenberg D, Turner LF, Defesche CL, Teoh KW, Johnson JH, Assenzo JR "Clinical safety of flurbiprofen." J Clin Pharmacol 30 (1990): 342-51
  • "Product Information. Dolobid (diflunisal)." Merck & Co, Inc, West Point, PA.
  • "Product Information. Tolectin (tolmetin)." McNeil Pharmaceutical, Raritan, NJ.
  • Concannon MJ, Meng L, Welsh CF, Puckett CL "Inhibition of perioperative platelet aggregation using toradol (ketorolac)." Ann Plast Surg 30 (1993): 264-6
  • "Product Information. Nalfon (fenoprofen)." Xspire Pharma, Ridgeland, MS.
  • Karachalios GN, Parigorakis JG "Thrombocytopenia and sulindac." Ann Intern Med 104 (1986): 128
  • Jick H, Derby LE, Garcia Rodriguez LA, Jick SS, Dean AD "Nonsteroidal antiinflammatory drugs and certain rare, serious adverse events: a cohort study." Pharmacotherapy 13 (1993): 212-7
  • Stambaugh JE Jr, Gordon RL, Geller R "Leukopenia and thrombocytopenia secondary to clinoril therapy." Lancet 2 (1980): 594
  • "Product Information. Voltaren (diclofenac)." Novartis Pharmaceuticals, East Hanover, NJ.
  • Robinson PM, Ahmed I "Diclofenac and post-tonsillectomy haemorrhage." Clin Otolaryngol 19 (1994): 344-5
  • Kim HL, Kovacs MJ "Diclofenac-associated thrombocytopenia and neutropenia." Ann Pharmacother 29 (1995): 713-5
  • "Product Information. Mobic (meloxicam)" Boehringer-Ingelheim, Ridgefield, CT.
  • Khazan U, Toth M, Mutgi A "Diclofenac sodium and bruising ." Ann Intern Med 112 (1990): 472-3
  • Schafer AI "Effects of nonsteroidal antiinflammatory drugs on platelet function and systemic hemostasis." J Clin Pharmacol 35 (1995): 209-19
  • "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn, Kalamazoo, MI.
  • "Product Information. Feldene (piroxicam)." Pfizer US Pharmaceuticals, New York, NY.
  • Poldre PA "Naproxen thrombocytopenia." Am J Hematol 31 (1989): 74
Topcare Ibuprofen

Nome generico: ibuprofen

Marchio commerciale: Advil, Midol, Motrin, Motrin IB, Motrin Migraine Pain, Proprinal, Smart Sense Children's Ibuprofen, PediaCare Children’s Pain Reliever/Fever Reducer, PediaCare Infant’s Pain Reliever/Fever Reducer, Advil Liqui-Gels, Caldolor, NeoProfen, Genpril, Ibu, Midol IB, Children's Motrin, Motrin Junior Strength

Sinonimo: Ibuprofen

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